Article
Genomewide screening for genes involved in biofilm formation and miconazole susceptibility in Saccharomyces cerevisiae.
FEMS yeast research - 1 Dec 2013
Vandenbosch Davy, De Canck Evelien, Dhondt Inne, Rigole Petra, Nelis Hans J, Coenye Tom
Abstract excerpt
Infections related to fungal biofilms are difficult to treat due to the reduced susceptibility of sessile cells to most antifungal agents. Previous research has shown that 1-10% of sessile Candida cells survive treatment with high doses of miconazole (a fungicidal imidazole). The aim of this study was to identify genes involved in fungal biofilm formation and to unravel the mechanisms of resistance of these...
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