Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene.

doi:10.1093/gerona/glv212

Article

Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Oct 2016

Yerges-Armstrong Laura M, Chai Sumbul, O'Connell Jeffery R, Curran Joanne E, Blangero John, Mitchell Braxton D, Shuldiner Alan R, Damcott Coleen M

Abstract excerpt

Although there is compelling evidence for a genetic contribution to longevity, identification of specific genes that robustly associate with longevity has been a challenge. In order to identify longevity-enhancing genes, we measured differential gene expression between offspring of long-lived Amish (older than 90 years; cases, n = 128) and spouses of these offspring (controls, n = 121) and correlated...

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Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene.

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