Article
Systematic Characterization of Long Noncoding RNAs Reveals the Contrasting Coordination of Cis- and Trans-Molecular Regulation in Human Fetal and Adult Hearts.
Circulation. Cardiovascular genetics - 1 Apr 2016
He Chunjiang, Hu Hanyang, Wilson Kitchener D, Wu Haodi, Feng Jing, Xia Siyu, Churko Jared, Qu Kun, Chang Howard Y, Wu Joseph C
Abstract excerpt
BACKGROUND: The molecular regulation of heart development is regulated by cis- and trans-factors acting on the genome and epigenome. As a class of important regulatory RNAs, the role of long noncoding RNAs (lncRNAs) in human heart development is still poorly understood. Furthermore, factors that interact with lncRNAs in this process are not well characterized. METHODS AND RESULTS: Using RNA sequencing, we...
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