Article
Improving cellulase production by Aspergillus niger using adaptive evolution.
Biotechnology letters - 1 Jun 2016
Patyshakuliyeva Aleksandrina, Arentshorst Mark, Allijn Iris E, Ram Arthur F J, de Vries Ronald P, Gelber Isabelle Benoit
Abstract excerpt
OBJECTIVES: To evaluate the potential of adaptive evolution as a tool in generating strains with an improved production of plant biomass degrading enzymes. RESULTS: An Aspergillus niger cellulase mutant was obtained by adaptive evolution. Physiological properties of this mutant revealed a five times higher cellulose production than the parental strain. Transcriptomic analysis revealed that the expression of noxR,...
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