Article
Alternative splicing of the angiogenesis associated extra-domain B of fibronectin regulates the accessibility of the B-C loop of the type III repeat 8.
PloS one - 10 Feb 2010
Ventura Elisa, Sassi Francesca, Parodi Arianna, Balza Enrica, Borsi Laura, Castellani Patrizia, Carnemolla Barbara, Zardi Luciano
Abstract excerpt
BACKGROUND: Fibronectin (FN) is a multi-domain molecule involved in many cellular processes, including tissue repair, embryogenesis, blood clotting, and cell migration/adhesion. The biological activities of FN are mediated by exposed loops located mainly at the interdomain interfaces that interact with various molecules such as, but not only, integrins. Different FN isoforms arise from the alternative splicing of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.