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Article

Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy.

The Journal of cell biology - 15 Feb 2016

Aratyn-Schaus Yvonne, Pasqualini Francesco S, Yuan Hongyan, McCain Megan L, Ye George J C, Sheehy Sean P, Campbell Patrick H, Parker Kevin Kit

Abstract excerpt

The efficacy of cardiac cell therapy depends on the integration of existing and newly formed cardiomyocytes. Here, we developed a minimal in vitro model of this interface by engineering two cell microtissues (μtissues) containing mouse cardiomyocytes, representing spared myocardium after injury, and cardiomyocytes generated from embryonic and induced pluripotent stem cells, to model newly formed cells. We...

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Identifiers

PMID: 26858266
DOI: 10.1083/jcb.201508026
PMCID: PMC4754718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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