Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of Association between MAP2K4 Gene Polymorphism rs3826392 and IL-1b Serum Level in Southern Chinese Han Ischemic Stroke Patients.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 May 2016

Gu Lian, Wu Yanli, Hu Shuyan, Chen Qing, Tan Jinjing, Yan Yan, Liang Baoyun, Tang Nong

Abstract excerpt

BACKGROUND: Mitogen-activated protein kinase kinase 4 (MAP2K4) gene acts as the direct upstream activator of c-Jun NH2-terminal kinase pathway, which plays an important role in regulating neuron survival and apoptosis in response to cerebral ischemia. However, the association between MAP2K4 gene polymorphisms and ischemic stroke (IS) has not yet been published. Therefore, this study investigates the association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Brain Ischemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homozygote

Share to Inflammation Mediators

Share to Interleukin-1beta

Share to MAP Kinase Kinase 4

Share to Stroke

Share to Up-Regulation

Source

Identifiers

PMID: 26856463
DOI: 10.1016/j.jstrokecerebrovasdis.2015.12.035

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of Association between MAP2K4 Gene Polymorphism rs3826392 and IL-1b Serum Level in Southern Chinese Han Ischemic Stroke Patients.PMID 26856463Read ↗

IGF2 confers genetic susceptibility to the risk of ischemic stroke with differential mRNA expression in leukocytesSemantic proximity Read ↗

TLR4 polymorphisms affect stroke risk and inflammatory response in Chinese ischemic stroke patients.Semantic proximity Read ↗

Polymorphisms in genes related to inflammation and endothelial function are associated with ischemic stroke and other vascular events in populations at high risk of stroke Short title: A community-based survey and cohort study in southwestern ChinaSemantic proximity Read ↗

Association Between TRAF6 Gene Polymorphisms and Susceptibility of Ischemic Stroke in Southern Chinese Han Population.Semantic proximity Read ↗

Genome-wide association analysis to search for new loci associated with stroke risk in Northwestern Chinese population.Semantic proximity Read ↗

Association of GWAS-Supported Variants rs2200733 and rs6843082 on Chromosome 4q25 with Ischemic Stroke in the Southern Chinese Han Population.Semantic proximity Read ↗

TNFSF4 gene polymorphism rs3861950 but not rs3850641 is associated with the risk of cerebral infarction in a Chinese population.Semantic proximity Read ↗

Impact of TLR5 rs5744174 on stroke risk, gene expression and on inflammatory cytokines, and lipid levels in stroke patients.Semantic proximity Read ↗

LncRNA SERPINB9P1 expression and polymorphisms are associated with ischemic stroke in a Chinese Han population.Semantic proximity Read ↗

IL-6R protective variant rs7529229 reduces interleukin-6 signaling and contributes to decreased ischemic stroke riskSemantic proximity Read ↗

The roles of MMP8/MMP10 polymorphisms in ischemic stroke susceptibility.Semantic proximity Read ↗

Correlations of MCP-1 -2518A>G polymorphism and serum levels with cerebral infarction risk: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.