Article
Sensitivity Profiles of Human Prostate Cancer Cell Lines to an 80 Kinase Inhibitor Panel.
Anticancer research - 1 Feb 2016
Burke Amy J, Ali Husnain, O'Connell Enda, Sullivan Francis J, Glynn Sharon A
Abstract excerpt
BACKGROUND: Taxanes and anti-androgen therapies are routinely used for the treatment of metastatic prostate cancer, however the majority of patients eventually develop resistance. MATERIALS AND METHODS: Eighty kinase inhibitors were screened regarding their ability to inhibit cell viability in CWR22, 22Rv1, PC-3 and DU145 prostate cancer cells using automated toxicity assays. Four kinase inhibitors were selected...
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