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Article

MET Amplification and Exon 14 Splice Site Mutation Define Unique Molecular Subgroups of Non-Small Cell Lung Carcinoma with Poor Prognosis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2016

Tong Joanna H, Yeung Sai F, Chan Anthony W H, Chung Lau Y, Chau Shuk L, Lung Raymond Wai Ming, Tong Carol Y, Chow Chit, Tin Edith K Y, Yu Yau H, Li Hui, Pan Yi, Chak Wing P, Ng Calvin S H, Mok Tony S K, To Ka F

Abstract excerpt

PURPOSE: Activation of MET oncogene as the result of amplification or activation mutation represents an emerging molecular target for cancer treatment. We comprehensively studied MET alterations and the clinicopathologic correlations in a large cohort of treatment-naïve non-small cell lung carcinoma (NSCLC). EXPERIMENTAL DESIGN: Six hundred eighty-seven NSCLCs were tested for MET exon 14 splicing site mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26847053
DOI: 10.1158/1078-0432.CCR-15-2061

Genes

MET
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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