PON-mt-tRNA: a multifactorial probability-based method for classification of mitochondrial tRNA variations.

Abstract excerpt

Transfer RNAs (tRNAs) are essential for encoding the transcribed genetic information from DNA into proteins. Variations in the human tRNAs are involved in diverse clinical phenotypes. Interestingly, all pathogenic variations in tRNAs are located in mitochondrial tRNAs (mt-tRNAs). Therefore, it is crucial to identify pathogenic variations in mt-tRNAs for disease diagnosis and proper treatment. We collected mt-tRNA...

Topics

• Anticodon
• Humans
• Machine Learning
• Mitochondria
• Models, Genetic
• Models, Molecular
• Models, Statistical
• Nucleic Acid Conformation
• Polymorphism, Single Nucleotide
• RNA
• RNA, Mitochondrial