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Article

Genetic variations in complement factors in patients with congenital thrombotic thrombocytopenic purpura with renal insufficiency.

International journal of hematology - 1 Mar 2016

Fan Xinping, Kremer Hovinga Johanna A, Shirotani-Ikejima Hiroko, Eura Yuka, Hirai Hidenori, Honda Shigenori, Kokame Koichi, Taleghani Magnus Mansouri, von Krogh Anne-Sophie, Yoshida Yoko, Fujimura Yoshihiro, Lämmle Bernhard, Miyata Toshiyuki

Abstract excerpt

The congenital form of thrombotic thrombocytopenic purpura (TTP) is caused by genetic mutations in ADAMTS13. Some, but not all, congenital TTP patients manifest renal insufficiency in addition to microangiopathic hemolysis and thrombocytopenia. We included 32 congenital TTP patients in the present study, which was designed to assess whether congenital TTP patients with renal insufficiency have predisposing...

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Share to ADAMTS13 Protein
Share to Atypical Hemolytic Uremic Syndrome

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Complement C3

Share to Genetic Association Studies

Share to Genetic Predisposition to Disease

Share to Mutation, Missense

Share to Purpura, Thrombotic Thrombocytopenic

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Source

Identifiers

PMID: 26830967
DOI: 10.1007/s12185-015-1933-7

Genes

ADAMTS13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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