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Article

Clinical Phenotypes and Genotypic Spectrum of Cystic Fibrosis in Chinese Children.

The Journal of pediatrics - 1 Apr 2016

Shen Yuelin, Liu Jinrong, Zhong Lili, Mogayzel Peter J, Zeitlin Pamela L, Sosnay Patrick R, Zhao Shunying

Abstract excerpt

OBJECTIVES: To characterize the clinical phenotypes and genotypic spectrum of cystic fibrosis (CF) in Chinese children. STUDY DESIGN: We recruited and characterized the phenotypes of 21 Chinese children with CF. All 27 exons and their flanking sequences of the CF transmembrane conductance regulator gene were amplified and sequenced to define the genotypes. RESULTS: Bronchiectasis (95.2%) and sinusitis (76.2%)...

Topics

3' Untranslated Regions
Adolescent
Asian People
Aspergillosis, Allergic Bronchopulmonary
Bronchiectasis
Child
China
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Exocrine Pancreatic Insufficiency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Exons

Female

Forced Expiratory Volume

Genotype

Humans

Male

Mutation

Phenotype

Source

Identifiers

PMID: 26826884
DOI: 10.1016/j.jpeds.2015.12.025

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