Article
Concordance in Anti-OmpC and Anti-I2 Indicate the Influence of Genetic Predisposition: Results of a European Study of Twins with Crohn's Disease.
Journal of Crohn's & colitis - 1 Jun 2016
Amcoff Karin, Joossens Marie, Pierik Marie J, Jonkers Daisy, Bohr Johan, Joossens Sofie, Romberg-Camps Mariëlle, Nyhlin Nils, Wickbom Anna, Rutgeerts Paul J, Tysk Curt, Bodin Lennart, Colombel Jean-Frederic, Vermeire Severine, Halfvarson Jonas
Abstract excerpt
BACKGROUND AND AIMS: An adaptive immunological response to microbial antigens has been observed in Crohn's disease (CD). Intriguingly, this serological response precedes the diagnosis in some patients and has also been observed in healthy relatives. We aimed to determine whether genetic factors are implicated in this response in a CD twin cohort. METHODS: In total, 82 twin pairs (Leuven n = 13, Maastricht n = 8,...
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