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Molecular Analysis of Sarcoidosis Granulomas Reveals Antimicrobial Targets

25 Jan 2016

Abstract excerpt

Sarcoidosis is a granulomatous disease of unknown cause. Prior molecular and immunologic studies have confirmed the presence of mycobacterial virulence factors, such as catalase peroxidase and superoxide dismutase A, within sarcoidosis granulomas. Molecular analysis of granulomas can identify targets of known antibiotics classes. Currently, major antibiotics are directed against DNA synthesis, protein synthesis,...

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PMID: 26807608
DOI: 10.1165/rcmb.2015-0212oc

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