Article
Comprehensive phenotypic characterization of PTLD reveals potential reliance on EBV or NF-κB signalling instead of B-cell receptor signalling.
Hematological oncology - 1 Jun 2017
Menter Thomas, Dickenmann Michael, Juskevicius Darius, Steiger Juerg, Dirnhofer Stephan, Tzankov Alexandar
Abstract excerpt
Post-transplant lymphoproliferative disorders (PTLD) are a major problem in transplant medicine. So far, the insights into pathogenesis and potentially druggable pathways in PTLD remain scarce. We investigated a cohort of PTLD patients, consisting of both polymorphic (n = 3) and monomorphic (n = 19) B-cell lymphoproliferations. Several signalling pathways, cell of origin of PTLD and their relation to viruses were...
Topics
- Adolescent
- Adult
- Child
- Cluster Analysis
- Epstein-Barr Virus Infections
- Female
- Humans
- Lymphoproliferative Disorders
- Male
- Middle Aged
- NF-kappa B
- Organ Transplantation
- Phenotype
- Receptors, Antigen, B-Cell