Article
Two novel SCN1A mutations identified in families with familial hemiplegic migraine.
Cephalalgia : an international journal of headache - 1 Nov 2014
Weller Claudia M, Pelzer Nadine, de Vries Boukje, López Mercè Artigas, De Fàbregues Oriol, Pascual Julio, Arroyo María A Ramos, Koelewijn Stephany C, Stam Anine H, Haan Joost, Ferrari Michel D, Terwindt Gisela M, van den Maagdenberg Arn M J M
Abstract excerpt
BACKGROUND: Familial hemiplegic migraine (FHM) is a rare monogenic subtype of migraine with aura, characterized by motor auras. The majority of FHM families have mutations in the CACNA1A and ATP1A2 genes; less than 5% of FHM families are explained by mutations in the SCN1A gene. Here we screened two Spanish FHM families for mutations in the FHM genes. METHODS: We assessed the clinical features of both FHM...
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