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Article

TBX5 mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians.

Cardiovascular research - 1 Mar 2016

Ma Ji-Fang, Yang Fan, Mahida Saagar N, Zhao Ling, Chen Xiaomin, Zhang Michael L, Sun Zhijun, Yao Yan, Zhang Yi-Xin, Zheng Gu-Yan, Dong Jie, Feng Ming-Jun, Zhang Rui, Sun Jian, Li Shuo, Wang Qun-Shan, Cao Huiqing, Benjamin Emelia J, Ellinor Patrick T, Li Yi-Gang, Tian Xiao-Li

Abstract excerpt

AIMS: Atrial fibrillation (AF) is a common arrhythmia with an important heritable aspect. The genetic factors underlying AF have not been fully elucidated. METHODS AND RESULTS: We screened six candidate genes (CAV1, KCNJ2, KCNQ1, NKX2.5, PITX2, and TBX5) for novel mutations in 139 patients of Chinese descent with early-onset AF and 576 controls. Four missense TBX5 mutations, p.R355C, p.Q376R, p.A428S, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26762269
DOI: 10.1093/cvr/cvw003
PMCID: PMC4752043

Genes

TBX5
CAV1
KCNJ2
KCNQ1
PITX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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