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Article

A Viral mRNA Motif at the 3'-Untranslated Region that Confers Translatability in a Cell-Specific Manner. Implications for Virus Evolution.

Scientific reports - 12 Jan 2016

Garcia-Moreno Manuel, Sanz Miguel Angel, Carrasco Luis

Abstract excerpt

Sindbis virus (SINV) mRNAs contain several motifs that participate in the regulation of their translation. We have discovered a motif at the 3' untranslated region (UTR) of viral mRNAs, constituted by three repeated sequences, which is involved in the translation of both SINV genomic and subgenomic mRNAs in insect, but not in mammalian cells. These data illustrate for the first time that an element present at the...

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Identifiers

PMID: 26755446
DOI: 10.1038/srep19217
PMCID: PMC4709744

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