Article
MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jul 2016
Browne Gillian, Dragon Julie A, Hong Deli, Messier Terri L, Gordon Jonathan A R, Farina Nicholas H, Boyd Joseph R, VanOudenhove Jennifer J, Perez Andrew W, Zaidi Sayyed K, Stein Janet L, Stein Gary S, Lian Jane B
Abstract excerpt
The Runx1 transcription factor, known for its essential role in normal hematopoiesis, was reported in limited studies to be mutated or associated with human breast tumor tissues. Runx1 increases concomitantly with disease progression in the MMTV-PyMT transgenic mouse model of breast cancer. Compelling questions relate to mechanisms that regulate Runx1 expression in breast cancer. Here, we tested the hypothesis...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.