Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.

doi:10.1161/JAHA.115.002257

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Article

Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.

Journal of the American Heart Association - 6 Jan 2016

Chen Qiumei, Varga Monika, Wang Xiaoyin, Haddad Daniel J, An Songtao, Medzikovic Lejla, Derakhshandeh Ronak, Kostyushev Dmitry S, Zhang Yan, Clifford Brian T, Luu Emmy, Danforth Olivia M, Rafikov Ruslan, Gong Wenhui, Black Stephen M, Suchkov Sergey V, Fineman Jeffrey R, Heiss Christian, Aschbacher Kirstin, Yeghiazarians Yerem, Springer Matthew L

Abstract excerpt

BACKGROUND: Circulating angiogenic cells (CACs) are peripheral blood cells whose functional capacity inversely correlates with cardiovascular risk and that have therapeutic benefits in animal models of cardiovascular disease. However, donor age and disease state influence the efficacy of autologous cell therapy. We sought to determine whether age or coronary artery disease (CAD) impairs the therapeutic potential...

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PMID: 26738788
DOI: 10.1161/JAHA.115.002257
PMCID: PMC4859354

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