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Article

Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer.

Molecular cancer - 5 Jan 2016

Chandler Paige, Kochupurakkal Bose S, Alam Samina, Richardson Andrea L, Soybel David I, Kelleher Shannon L

Abstract excerpt

BACKGROUND: Zinc (Zn) hyper-accumulates in breast tumors and malignant cell lines compared to normal mammary epithelium. The mechanisms responsible for Zn accumulation and the consequence of Zn dysregulation are poorly understood. METHODS: Microarrays were performed to assess differences in the expression of Zn transporters and metallothioneins (MTs) in human breast tumors and breast cancer cell lines. Real-time...

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PMID: 26728511
DOI: 10.1186/s12943-015-0486-y
PMCID: PMC4700748

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