Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing.

Expert opinion on drug metabolism & toxicology - 1 Jan 2016

Roses Allen D, Akkari P Anthony, Chiba-Falek Ornit, Lutz Michael W, Gottschalk William Kirby, Saunders Ann Marie, Saul Bob, Sundseth Scott, Burns Daniel

Abstract excerpt

INTRODUCTION: In this article we discuss several human neurological diseases and their relationship to specific highly polymorphic small structural variants (SVs). Unlike genome-wide association analysis (GWAS), this methodology is not a genome screen to define new possibly associated genes, requiring statistical corrections for a million association tests. SVs provide local mapping information at a specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Exons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genome-Wide Association Study

Share to Lewy Body Disease

Share to Microsatellite Repeats

Share to Parkinson Disease

Share to Prognosis

Source

Identifiers

PMID: 26727306
DOI: 10.1517/17425255.2016.1133586

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing.PMID 26727306Read ↗

Polyallelic structural variants can provide accurate, highly informative genetic markers focused on diagnosis and therapeutic targets: Accuracy vs. Precision.Semantic proximity Read ↗

Structural variants linked to Alzheimer's disease and other common age-related clinical and neuropathologic traits.Semantic proximity Read ↗

The Role of Structural Variants in the Genetic Architecture of Parkinson's Disease.Semantic proximity Read ↗

Structural genomic variations and Parkinson's disease.Semantic proximity Read ↗

Towards accurate and reliable resolution of structural variants for clinical diagnosis.Semantic proximity Read ↗

Structural Variants May Be a Source of Missing Heritability in sALSSemantic proximity Read ↗

Structural variation detection and association analysis of whole-genome-sequence data from 16,543 Alzheimer's disease sequencing project subjects.Semantic proximity Read ↗

Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear PalsySemantic proximity Read ↗

Genome-wide structural variant analysis identifies risk loci for non-Alzheimer’s dementiasSemantic proximity Read ↗

Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer’s Diseases Sequencing Project SubjectsSemantic proximity Read ↗

A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes.Semantic proximity Read ↗

Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.