Article
A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes.
Nature communications - 4 Nov 2024
Tan Joanna Hui Juan, Li Zhihui, Porta Mar Gonzalez, Rajaby Ramesh, Lim Weng Khong, Tan Ye An, Jimenez Rodrigo Toro, Teo Renyi, Hebrard Maxime, Ow Jack Ling, Ang Shimin, Jeyakani Justin, Chong Yap Seng, Lim Tock Han, Goh Liuh Ling, Tham Yih Chung, Leong Khai Pang, Chin Calvin Woon Loong, Davila Sonia, Karnani Neerja, Cheng Ching-Yu, Chambers John, Tai E Shyong, Liu Jianjun, Sim Xueling, Sung Wing Kin, Prabhakar Shyam, Tan Patrick, Bertin Nicolas
Abstract excerpt
Structural variants (SVs) are significant contributors to inter-individual genetic variation associated with traits and diseases. Current SV studies using whole-genome sequencing (WGS) have a largely Eurocentric composition, with little known about SV diversity in other ancestries, particularly from Asia. Here, we present a WGS catalogue of 73,035 SVs from 8392 Singaporeans of East Asian, Southeast Asian and...
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