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Article

[Research Progress on Treating Acute Myeloid Leukemia by Midostaurin].

Zhongguo shi yan xue ye xue za zhi - 1 Dec 2015

Wang Yin-Ying, Sun Wan-Ling

Abstract excerpt

FLT3 gene mutations occurred in approximately 30% of acute myeloid leukemia (AML) patients, which is closely associated with the occurrence, development and poor prognosis of AML. The therapy targeting at FLT3 mutations might be a promising treatment for AML. Midostaurin can inhibit the activities of III receptor tyrosine kinase encoded by FLT3 gene, induce cell cycle arrest and has a apoptotic effect on...

Topics

Humans
Leukemia, Myeloid, Acute
Mutation
Staurosporine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26708910
DOI: 10.7534/j.issn.1009-2137.2015.06.045

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26708910-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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