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Article

Identification of Gender-Specific Genetic Variants in Patients With Bicuspid Aortic Valve.

The American journal of cardiology - 1 Feb 2016

Dargis Natasha, Lamontagne Maxime, Gaudreault Nathalie, Sbarra Laura, Henry Cyndi, Pibarot Philippe, Mathieu Patrick, Bossé Yohan

Abstract excerpt

Bicuspid aortic valve (BAV) is the most frequent congenital heart defect and has a male predominance of 3 to 1. A large proportion of patients develop valvular and aortic complications. Despite the high prevalence of BAV, its cause and genetic origins remain elusive. The goal of this study was to identify genetic variants associated with BAV. Nine genes previously associated with BAV (NOTCH1, AXIN1, EGFR, ENG,...

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Source

Identifiers

PMID: 26708639
DOI: 10.1016/j.amjcard.2015.10.058

Genes

EGFR
NOTCH1
TGFBR2
AXIN1
ENG
GATA5
NOS3
PDIA2
TEX26

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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