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Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics

22 Dec 2015

Abstract excerpt

To identify candidate serum molecule biomarkers for the non-invasive early prenatal diagnosis of neural tube defects (NTDs), we employed an iTRAQ-based quantitative proteomic approach to analyze the proteomic changes in serum samples from embryonic day (E) 11 and E13 pregnant rats with spina bifida aperta (SBA) induced by all-trans retinoic acid. Among the 390 proteins identified, 40 proteins at E11 and 26...

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Share to Fetal and Pediatric Neurological Disorders
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26691006
DOI: 10.1038/srep17559

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