Article
Inhibition of mutant KrasG12D-initiated murine pancreatic carcinoma growth by a dual c-Raf and soluble epoxide hydrolase inhibitor t-CUPM.
Cancer letters - 28 Feb 2016
Liao Jie, Hwang Sung Hee, Li Haonan, Yang Yihe, Yang Jun, Wecksler Aaron T, Liu Jun-Yan, Hammock Bruce D, Yang Guang-Yu
Abstract excerpt
Mutant Kras and chronic pancreatitis are the most common pathological events involved in human pancreatic cancer. It has been demonstrated that c-Raf is responsible for transmitting signals from mutant Ras to its downstream signals including MEK-ERK and for initiating carcinogenesis. The soluble epoxide hydrolase (sEH), a pro-inflammatory enzyme, generally inactivates anti-inflammatory and anti-pain...
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