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A stereo configuration-activity study of 3-iodo-4-(2-methylcyclohexyloxy)-6-phenethylpyridin-2(2H)-ones as potency inhibitors of HIV-1 variants.

Organic & biomolecular chemistry - 28 Jan 2016

Wu Shaotong, Yin Qianqian, Zhao Liang, Fan Ningning, Tang Xiaowan, Zhao Jianxiong, Sheng Tao, Guo Ying, Tian Chao, Zhang Zhili, Xu Weisi, Liu Zhenming, Jiang Shibo, Ma Liying, Liu Junyi, Wang Xiaowei

Abstract excerpt

3-Iodo-4-(2'-methylcyclohexyloxy)-6-phenethylpyridin-2(1H)-ones, as effective non-nucleoside reverse transcriptase inhibitors, were synthesized and resolved with different configurations. Biological results revealed that the trans-racemate 2b exhibited more potent activity than the cis-isomers. Noticeably, the trans-(S,S)-enantiomer 2e turned out to be significantly more potent than its counterpart enantiomer 2d...

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Identifiers

PMID: 26676723
DOI: 10.1039/c5ob02154e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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