Article
Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.
Gut - 1 Feb 2017
Garnelo Marta, Tan Alex, Her Zhisheng, Yeong Joe, Lim Chun Jye, Chen Jinmiao, Lim Kiat Hon, Weber Achim, Chow Pierce, Chung Alexander, Ooi London Lucien Pj, Toh Han Chong, Heikenwalder Mathias, Ng Irene O L, Nardin Alessandra, Chen Qingfeng, Abastado Jean-Pierre, Chew Valerie
Abstract excerpt
OBJECTIVE: The nature of the tumour-infiltrating leucocytes (TILs) is known to impact clinical outcome in carcinomas, including hepatocellular carcinoma (HCC). However, the role of tumour-infiltrating B cells (TIBs) remains controversial. Here, we investigate the impact of TIBs and their interaction with T cells on HCC patient prognosis. DESIGN: Tissue samples were obtained from 112 patients with HCC from...
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