Article
Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins.
Autophagy - 1 Jan 2016
Mouna Lina, Hernandez Eva, Bonte Dorine, Brost Rebekka, Amazit Larbi, Delgui Laura R, Brune Wolfram, Geballe Adam P, Beau Isabelle, Esclatine Audrey
Abstract excerpt
Autophagy is activated early after human cytomegalovirus (HCMV) infection but, later on, the virus blocks autophagy. Here we characterized 2 HCMV proteins, TRS1 and IRS1, which inhibit autophagy during infection. Expression of either TRS1 or IRS1 was able to block autophagy in different cell lines, independently of the EIF2S1 kinase, EIF2AK2/PKR. Instead, TRS1 and IRS1 interacted with the autophagy protein...
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