Article
Targeted silver nanoparticles for ratiometric cell phenotyping.
Nanoscale - 28 Apr 2016
Willmore Anne-Mari A, Simón-Gracia Lorena, Toome Kadri, Paiste Päärn, Kotamraju Venkata Ramana, Mölder Tarmo, Sugahara Kazuki N, Ruoslahti Erkki, Braun Gary B, Teesalu Tambet
Abstract excerpt
Affinity targeting is used to deliver nanoparticles to cells and tissues. For efficient targeting, it is critical to consider the expression and accessibility of the relevant receptors in the target cells. Here, we describe isotopically barcoded silver nanoparticles (AgNPs) as a tool for auditing affinity ligand receptors in cells. Tumor penetrating peptide RPARPAR (receptor: NRP-1) and tumor homing peptide GKRK...
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