Article
Regulatory B cells contribute to the impaired antitumor immunity in ovarian cancer patients.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 May 2016
Wei Xin, Jin Yangqiu, Tian Yinpu, Zhang Huiyuan, Wu Jie, Lu Wei, Lu Xiaofen
Abstract excerpt
Multiple factors in the tumor microenvironment were found to inhibit antitumor adaptive immune responses, allowing tumor persistence and growth. In this study, ascites from ovarian cancer patients were collected. We observed that a population of interleukin-10(+) B (IL-10(+) B) cells was preferentially enriched in the ascites. This population was associated with naive B cell phenotype or IgM or class-switched...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
