Article
Biomarker Analysis in a Phase II Study of Sunitinib in Patients with Advanced Melanoma.
Anticancer research - 1 Dec 2015
Decoster Lore, Vande Broek Isabelle, Neyns Bart, Majois Françoise, Baurain Jean François, Rottey Sylvie, Rorive Andrée, Anckaert Ellen, De Mey Johan, De Brakeleer Sylvia, De Grève Jacques
Abstract excerpt
AIM: To investigate the efficacy of sunitinib in patients with advanced melanoma and to correlate angiogenic biomarkers with response and survival. PATIENTS AND METHODS: We performed a phase II study in patients with advanced pre-treated melanoma. The primary endpoint was tumor response. Blood samples for biomarker analysis including vascular endothelial growth factor (VEGF), and its receptors VEGFR1 and -2,...
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