Article
MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours.
Nature communications - 4 Dec 2015
Perlman Elizabeth J, Gadd Samantha, Arold Stefan T, Radhakrishnan Anand, Gerhard Daniela S, Jennings Lawrence, Huff Vicki, Guidry Auvil Jaime M, Davidsen Tanja M, Dome Jeffrey S, Meerzaman Daoud, Hsu Chih Hao, Nguyen Cu, Anderson James, Ma Yussanne, Mungall Andrew J, Moore Richard A, Marra Marco A, Mullighan Charles G, Ma Jing, Wheeler David A, Hampton Oliver A, Gastier-Foster Julie M, Ross Nicole, Smith Malcolm A
Abstract excerpt
Wilms tumour is an embryonal tumour of childhood that closely resembles the developing kidney. Genomic changes responsible for the development of the majority of Wilms tumours remain largely unknown. Here we identify recurrent mutations within Wilms tumours that involve the highly conserved YEATS domain of MLLT1 (ENL), a gene known to be involved in transcriptional elongation during early development. The mutant...
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