Article
Functional dissection of the epidermal growth factor receptor epitopes targeted by panitumumab and cetuximab.
Neoplasia (New York, N.Y.) - 1 Nov 2012
Voigt Mareike, Braig Friederike, Göthel Markus, Schulte Alexander, Lamszus Katrin, Bokemeyer Carsten, Binder Mascha
Abstract excerpt
Cetuximab and panitumumab, two antibodies targeting the extracellular domain of the epidermal growth factor receptor (EGFR), are of major clinical importance particularly in the treatment of metastatic colorectal cancer. As patients may acquire resistance-mediating mutations within the extracellular EGFR domain, functional dissection of the exact binding sites of EGFR targeting antibodies may help predict...
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