Article
Peroxisomes, lipid droplets, and endoplasmic reticulum "hitchhike" on motile early endosomes.
The Journal of cell biology - 7 Dec 2015
Guimaraes Sofia C, Schuster Martin, Bielska Ewa, Dagdas Gulay, Kilaru Sreedhar, Meadows Ben R A, Schrader Michael, Steinberg Gero
Abstract excerpt
Intracellular transport is mediated by molecular motors that bind cargo to be transported along the cytoskeleton. Here, we report, for the first time, that peroxisomes (POs), lipid droplets (LDs), and the endoplasmic reticulum (ER) rely on early endosomes (EEs) for intracellular movement in a fungal model system. We show that POs undergo kinesin-3- and dynein-dependent transport along microtubules. Surprisingly,...
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