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Article

IL-10-producing regulatory B cells are decreased in patients with psoriasis.

Journal of dermatological science - 1 Feb 2016

Hayashi Mitsuha, Yanaba Koichi, Umezawa Yoshinori, Yoshihara Yuki, Kikuchi Sota, Ishiuji Yozo, Saeki Hidehisa, Nakagawa Hidemi

Abstract excerpt

BACKGROUNDS: Interleukin (IL)-10-producing regulatory B cells (B10 cells) have been shown to ameliorate psoriasis in mice. Human B10 progenitor cells are characterized as CD19(+)CD24(hi)CD38(hi) B cells that exert their regulatory functions via the production of IL-10. However, the role of B10 cells in the pathogenesis of psoriasis remains unclear. OBJECTIVES: We examined B10 cells in patients with psoriasis and...

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Identifiers

PMID: 26614745
DOI: 10.1016/j.jdermsci.2015.11.003

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