Article
Population Structure Shapes Copy Number Variation in Malaria Parasites.
Molecular biology and evolution - 1 Mar 2016
Cheeseman Ian H, Miller Becky, Tan John C, Tan Asako, Nair Shalini, Nkhoma Standwell C, De Donato Marcos, Rodulfo Hectorina, Dondorp Arjen, Branch Oralee H, Mesia Lastenia Ruiz, Newton Paul, Mayxay Mayfong, Amambua-Ngwa Alfred, Conway David J, Nosten François, Ferdig Michael T, Anderson Tim J C
Abstract excerpt
If copy number variants (CNVs) are predominantly deleterious, we would expect them to be more efficiently purged from populations with a large effective population size (Ne) than from populations with a small Ne. Malaria parasites (Plasmodium falciparum) provide an excellent organism to examine this prediction, because this protozoan shows a broad spectrum of population structures within a single species, with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.