Article
Neuroprotective effects of Cerebrolysin in triple repeat Tau transgenic model of Pick's disease and fronto-temporal tauopathies.
BMC neuroscience - 26 Nov 2015
Rockenstein Edward, Ubhi Kiren, Mante Michael, Florio Jazmin, Adame Anthony, Winter Stefan, Brandstaetter Hemma, Meier Dieter, Masliah Eliezer
Abstract excerpt
BACKGROUND: Tauopathies are a group of neurodegenerative disorders with accumulation of three-repeat (3R) or four-repeat (4R) Tau. While 3R tau is found in Pick's disease and Alzheimer's disease (AD), 4R tau is more abundant in corticobasal degeneration, progressive supranuclear palsy, and AD. We have previously shown that Cerebrolysin™ (CBL), a neuropeptide mixture with neurotrophic effects, ameliorates the...
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