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Costunolide induces lung adenocarcinoma cell line A549 cells apoptosis through ROS (reactive oxygen species)—mediated endoplasmic reticulum stress

26 Nov 2015

Abstract excerpt

Costunolide is an active sesquiterpene lactone derived from many herbal medicines. It has a broad spectrum of bioactivities, including anti-inflammatory and potential anti-tumor effects. The aims of the present study were to evaluate the inhibitory effects of costunolide on A549 cell growth and to explore the underlying molecular mechanisms. Annexin V-FITC/PI flow cytometry analysis revealed that costunolide...

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PMID: 26609913
DOI: 10.1002/cbin.10564

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