Article
miR-190a inhibits epithelial-mesenchymal transition of hepatoma cells via targeting the long non-coding RNA treRNA.
FEBS letters - 21 Dec 2015
Wang Xinyu, Ren Yanli, Yang Xinyu, Xiong Xiangyu, Han Sichong, Ge Yunxia, Pan Wenting, Zhou Liqing, Yuan Qipeng, Yang Ming
Abstract excerpt
treRNA is a long non-coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR-190a can silence treRNA post-transcriptionally. Suppression of treRNA by miR-190a led to significant changes of mesenchymal-epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR-190a exhibited lower expression in hepatoma tissues,...
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