Article
Unraveling EGFR-TKI resistance in lung cancer with high PD-L1 or TMB in EGFR-sensitive mutations.
Respiratory research - 18 Jan 2024
Ding Wuwu, Yang Pengmin, Zhao Xiaokai, Wang Xiaozhi, Liu Huaqing, Su Qing, Wang Xintao, Li Jieyi, Gong Ziying, Zhang Daoyun, Wang Xinwei
Abstract excerpt
BACKGROUND: Although EGFR-TKI resistance mechanisms in non-small cell lung cancer (NSCLC) have been extensively studied, certain patient subgroups remain with unclear mechanisms. This retrospective study analysed mutation data of NSCLC patients with EGFR-sensitive mutations and high programmed death-ligand 1 (PD-L1) expression or high TMB to identify primary resistance mechanisms. METHODS: Hybrid capture-based...
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