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Article

MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells.

PloS one - 1 Jan 2015

Presutti Dario, Santini Simonetta, Cardinali Beatrice, Papoff Giuliana, Lalli Cristiana, Samperna Simone, Fustaino Valentina, Giannini Giuseppe, Ruberti Giovina

Abstract excerpt

Epidermal growth factor receptor (EGFR), member of the human epidermal growth factor receptor (HER) family, plays a critical role in regulating multiple cellular processes including proliferation, differentiation, cell migration and cell survival. Deregulation of the EGFR signaling has been found to be associated with the development of a variety of human malignancies including lung, breast, and ovarian cancers,...

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Topics

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Share to Carcinogenesis
Share to Erlotinib Hydrochloride

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Gene Amplification

Share to Inhibitory Concentration 50

Share to Proto-Oncogene Proteins c-met

Share to Receptor, ErbB-2

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Source

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Identifiers

PMID: 26580964
DOI: 10.1371/journal.pone.0143333
PMCID: PMC4651538

Genes

EGFR
MET
AXL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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