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Article

Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2013

Yu Helena A, Arcila Maria E, Rekhtman Natasha, Sima Camelia S, Zakowski Maureen F, Pao William, Kris Mark G, Miller Vincent A, Ladanyi Marc, Riely Gregory J

Abstract excerpt

PURPOSE: All patients with EGF receptor (EGFR)-mutant lung cancers eventually develop acquired resistance to EGFR tyrosine kinase inhibitors (TKI). Smaller series have identified various mechanisms of resistance, but systematic evaluation of a large number of patients to definitively establish the frequency of various mechanisms has not been conducted. EXPERIMENTAL DESIGN: Patients with lung adenocarcinomas and...

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Identifiers

PMID: 23470965
DOI: 10.1158/1078-0432.CCR-12-2246
PMCID: PMC3630270

Genes

EGFR
MET
AKT1
BRAF
ERBB2
KRAS
NRAS
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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