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Article

Prolonged and Severe Gestational Thyrotoxicosis Due to Enhanced hCG Sensitivity of a Mutant Thyrotropin Receptor.

The Journal of clinical endocrinology and metabolism - 1 Jan 2016

Coulon Anne Laure, Savagner Frédérique, Briet Claire, Vernin Marie, Munier Mathilde, Chabre Olivier, Rodien Patrice

Abstract excerpt

CONTEXT: Gestational thyrotoxicosis, whether associated with hyperemesis gravidarum or not, is thought to be due to excessive human chorionic gonadotropin (hCG) secretion. CASE DESCRIPTION: We report here the second case of gestational thyrotoxicosis associated with hyperemesis gravidarum due to a mutation of the TSH receptor, providing thyroid hypersensitivity to hCG. CONCLUSION: Severe and lasting gestational...

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Source

Identifiers

PMID: 26580241
DOI: 10.1210/jc.2015-3670

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