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Article

Dapper homolog 1 alpha suppresses metastasis ability of gastric cancer through inhibiting planar cell polarity pathway.

Oncotarget - 6 Dec 2016

Liu Yuegeng, Zhang Jingwan, Yu Weifang, Zhang Xiaoming, Wang Guiqi, Zhao Zengren

Abstract excerpt

Dapper homolog 1 alpha (DACT1α) is a member of DACT family and an important regulator in the planar cell polarity pathway. We aim to clarify its functional role in metastasis ability of gastric cancer. DACT1α was silenced in all gastric cancer cell lines (8/8), but expressed in normal gastric tissue. Ectopic expression of DACT1α in silenced gastric cancer cell lines (AGS, BGC823 and MGC803) by stable transfection...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27833078
DOI: 10.18632/oncotarget.13234
PMCID: PMC5348403

Genes

ITGA1
ITGA2
ITGA3
ITGB3
MCAM
MMP9
PDGFB
PLAU
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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