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Article

Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jan 2016

Deenen Maarten J, Meulendijks Didier, Cats Annemieke, Sechterberger Marjolein K, Severens Johan L, Boot Henk, Smits Paul H, Rosing Hilde, Mandigers Caroline M P W, Soesan Marcel, Beijnen Jos H, Schellens Jan H M

Abstract excerpt

PURPOSE: Fluoropyrimidines are frequently prescribed anticancer drugs. A polymorphism in the fluoropyrimidine metabolizing enzyme dihydropyrimidine dehydrogenase (DPD; ie, DPYD*2A) is strongly associated with fluoropyrimidine-induced severe and life-threatening toxicity. This study determined the feasibility, safety, and cost of DPYD*2A genotype-guided dosing. PATIENTS AND METHODS: Patients intended to be treated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26573078
DOI: 10.1200/JCO.2015.63.1325

Genes

DPYD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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