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Article

Glutathione S-Transferase Gene Polymorphisms and Treatment Outcome in Cervical Cancer Patients under Concomitant Chemoradiation.

PloS one - 1 Jan 2015

Abbas Mohammad, Kushwaha Vandana Singh, Srivastava Kirti, Banerjee Monisha

Abstract excerpt

PURPOSE: Cisplatin based concomitant chemoradiation (CRT) is the standard treatment for locally advanced cervical cancer (CC). Glutathione S-transferase (GST), a phase II antioxidant enzyme is induced by oxidative stress generated by drugs and reactive oxidants. The present study was undertaken to evaluate the association of GSTM1, T1 and P1 polymorphisms with the outcome of CRT treatment in CC patients. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26571237
DOI: 10.1371/journal.pone.0142501
PMCID: PMC4646353

Genes

GSTM1
GSTP1
GSTT1

Provenance

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Glutathione S-Transferase Gene Polymorphisms and Treatment Outcome in Cervical Cancer Patients under Concomitant Chemoradiation.PMID 26571237Read ↗

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GSTM1 polymorphism, GSTT1 polymorphism, and cervical cancer risk: a meta-analysis.Semantic proximity Read ↗

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