Coevolved Mutations Reveal Distinct Architectures for Two Core Proteins in the Bacterial Flagellar Motor.

Abstract excerpt

Switching of bacterial flagellar rotation is caused by large domain movements of the FliG protein triggered by binding of the signal protein CheY to FliM. FliG and FliM form adjacent multi-subunit arrays within the basal body C-ring. The movements alter the interaction of the FliG C-terminal (FliGC) "torque" helix with the stator complexes. Atomic models based on the Salmonella entrovar C-ring electron microscopy...

Topics

• Algorithms
• Amino Acid Sequence
• Bacterial Proteins
• Computer Simulation
• Crystallography, X-Ray
• Evolution, Molecular
• Flagella
• Models, Genetic
• Models, Molecular
• Mutation
• Phylogeny