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Article

The role of ADAMTS-13 activity and complement mutational analysis in differentiating acute thrombotic microangiopathies.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2016

Phillips E H, Westwood J P, Brocklebank V, Wong E K S, Tellez J O, Marchbank K J, McGuckin S, Gale D P, Connolly J, Goodship T H J, Kavanagh D, Scully M A

Abstract excerpt

UNLABELLED: ESSENTIALS: Molecular diagnostics has improved the differentiation of acute thrombotic microangiopathys (TMAs). Atypical hemolytic uremic syndrome may have features mimicking thrombotic thrombocytopenic purpura. We identified novel complement mutations and a high incidence of CD46, with favorable long term outcomes. Complement mutation analysis in TMA where the diagnosis is unclear and ADAMTS-13...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26559391
DOI: 10.1111/jth.13189
PMCID: PMC4737436

Genes

CFB
CFH
CFI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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